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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TGFB1
All Species:
13.03
Human Site:
S273
Identified Species:
35.83
UniProt:
P01137
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P01137
NP_000651.3
390
44341
S273
E
R
A
Q
H
L
Q
S
S
R
H
R
R
A
L
Chimpanzee
Pan troglodytes
XP_001161571
412
47357
G295
L
D
N
P
G
Q
G
G
Q
R
K
K
R
A
L
Rhesus Macaque
Macaca mulatta
XP_001100842
390
44204
V273
Q
S
S
L
H
E
R
V
R
S
H
L
K
K
K
Dog
Lupus familis
XP_547918
412
47392
G295
L
D
N
P
G
Q
G
G
Q
R
K
K
R
A
L
Cat
Felis silvestris
Mouse
Mus musculus
P04202
390
44291
S273
E
R
A
Q
H
L
H
S
S
R
H
R
R
A
L
Rat
Rattus norvegicus
P17246
390
44310
S273
E
R
A
Q
H
L
H
S
S
R
H
R
R
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P09531
373
42616
R258
E
L
H
S
A
R
R
R
R
D
L
D
T
D
Y
Frog
Xenopus laevis
P16176
382
44182
S265
E
R
I
D
T
V
T
S
S
R
K
K
R
G
V
Zebra Danio
Brachydanio rerio
NP_919367
410
46964
S293
R
L
D
V
L
P
T
S
R
R
R
K
R
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.3
85.1
46.1
N.A.
89.7
90
N.A.
N.A.
55.3
49.2
46.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
61.4
88.9
60.4
N.A.
93.8
93.5
N.A.
N.A.
67.4
63.3
62.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
26.6
13.3
26.6
N.A.
93.3
93.3
N.A.
N.A.
6.6
40
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
33.3
40
33.3
N.A.
93.3
93.3
N.A.
N.A.
13.3
60
40
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
34
0
12
0
0
0
0
0
0
0
0
67
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
23
12
12
0
0
0
0
0
12
0
12
0
12
0
% D
% Glu:
56
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
23
0
23
23
0
0
0
0
0
12
0
% G
% His:
0
0
12
0
45
0
23
0
0
0
45
0
0
0
0
% H
% Ile:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
34
45
12
12
12
% K
% Leu:
23
23
0
12
12
34
0
0
0
0
12
12
0
0
67
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
23
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
23
0
12
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
0
0
34
0
23
12
0
23
0
0
0
0
0
0
% Q
% Arg:
12
45
0
0
0
12
23
12
34
78
12
34
78
0
0
% R
% Ser:
0
12
12
12
0
0
0
56
45
12
0
0
0
0
0
% S
% Thr:
0
0
0
0
12
0
23
0
0
0
0
0
12
0
0
% T
% Val:
0
0
0
12
0
12
0
12
0
0
0
0
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _